Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms
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چکیده
منابع مشابه
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms
α(2)-Macroglobulin (α(2)M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of α(2)M with proteases results in an 'activated' conformation, where the proteases become covalently-linked within the interior of a cage-like structure formed by α(2)M. This study investigates, the effect of activation on the ability of α(2)M to inhibit amyloid form...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2013
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2013.01.020